Department of Dermatology, Peking University People's Hospital, Beijing, China.
J Am Acad Dermatol. 2013 Jul;69(1):34-9. doi: 10.1016/j.jaad.2012.12.970. Epub 2013 Feb 1.
Graft-versus-host disease (GVHD) is a systemic disease, and skin is often one of the target organs. An atopic dermatitis (AD)-like presentation has never to our knowledge been reported.
We sought to describe an AD-like presentation of cutaneous GVHD.
Data on 11 patients with an AD-like presentation of GVHD were collected. The clinical and laboratory findings were retrospectively studied.
All 11 patients developed skin lesions after hematopoietic stem-cell transplantation. The skin lesions occurred between 2 to 12 months after transplantation. Eight patients received their transplant from a first-degree family member; 3 received their transplant from an unrelated donor. The skin lesions were pruritic and suggestive of AD, whereas the histology showed features of AD and GVHD. The lesions responded to topical and systemic anti-inflammatory and immunosuppressive therapy and phototherapy.
The number of patients is small and the study is retrospective.
AD-like GVHD might represent a novel form of chronic cutaneous GVHD and responds well to treatment.
移植物抗宿主病（GVHD）是一种系统性疾病，皮肤通常是其靶器官之一。据我们所知，从未有过类似特应性皮炎（AD）的表现。
我们旨在描述一种类似 AD 的皮肤 GVHD 表现。
收集了 11 例 GVHD 类似 AD 表现的患者的数据。回顾性研究了临床和实验室发现。
所有 11 例患者在造血干细胞移植后均出现皮肤病变。皮肤病变发生在移植后 2 至 12 个月之间。8 例患者接受了一级亲属的移植；3 例患者接受了无关供体的移植。皮肤病变伴有瘙痒，提示 AD，而组织学表现为 AD 和 GVHD 的特征。病变对局部和全身抗炎和免疫抑制治疗以及光疗有反应。
患者数量较少，且研究为回顾性。
类似 AD 的 GVHD 可能代表一种新型慢性皮肤 GVHD，对治疗反应良好。
