Department of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
J Neuroimmunol. 2013 Apr 15;257(1-2):13-20. doi: 10.1016/j.jneuroim.2013.01.004. Epub 2013 Feb 1.
Oligodendroglia are cells of the central nervous system (CNS) that form myelin sheath, which insulates neuronal axons. Neuropathologies of the CNS include dysmyelination of axons in multiple sclerosis and CNS trauma. Cell replacement is a promising but largely untested therapy for dysmyelination. Shiverer mouse, a genetic mutant that does not synthesize full-length myelin basic protein (MBP), a critical prerequisite protein in CNS myelin sheath formation, provides an unequivocal model for determining the potential of stem cells to become oligodendroglia. We demonstrate that adult wild-type mouse bone marrow stem cells can express MBP and ensheath axons when transplanted into Shiverer brain.
少突胶质细胞是中枢神经系统 (CNS) 的细胞，形成髓鞘，为神经元轴突提供绝缘。CNS 的神经病理学包括多发性硬化症和 CNS 创伤中的轴突脱髓鞘。细胞替代是一种有前途但在很大程度上未经测试的脱髓鞘治疗方法。Shiverer 小鼠是一种遗传突变体，不能合成全长髓鞘碱性蛋白 (MBP)，这是 CNS 髓鞘形成的关键前提蛋白，为确定干细胞成为少突胶质细胞的潜力提供了一个明确的模型。我们证明，当移植到 Shiverer 大脑中时，成年野生型小鼠骨髓干细胞可以表达 MBP 并包裹轴突。
