Geller I, Gause E, Hartmann R J, Seifter J
Department of Behavioral and Environmental Sciences, Southwest Foundation for Research and Education, San Antonio, TX 78284.
Neurobehav Toxicol. 1979;1 Suppl 1:9-13.
This study involved the application of discrimination behavior for the study of effects of environmental contaminants on the behavior of laboratory animals. Polybrominated biphenyl (PBB) was evaluated for effects on the acquisition and performance of a simple auditory discrimination by rats. Methyl ethyl ketone (MEK), methyl isobutyl ketone (MIBK) and carbon monoxide (CO) were evaluated for effects on a delayed match-to-sample discrimination task in the juvenile baboon. All of the contaminants slowed response times and increased extra responses. These findings suggest that discrimination behavior may be of value for the evaluation of environmental contaminants for effects on the central nervous system.
本研究涉及运用辨别行为来研究环境污染物对实验动物行为的影响。评估了多溴联苯（PBB）对大鼠简单听觉辨别的习得和表现的影响。评估了甲乙酮（MEK）、甲基异丁基酮（MIBK）和一氧化碳（CO）对幼年狒狒延迟样本匹配辨别任务的影响。所有污染物均使反应时间变慢并增加了额外反应。这些发现表明，辨别行为对于评估环境污染物对中枢神经系统的影响可能具有价值。
