Sherenesheva N I
Biull Eksp Biol Med. 1990 Feb;109(2):175-6.
Peculiarities of carcinogenic effect of N-methyl-N'-nitro-N-nitrosoguanidine administered through a stomach tube on rats were studied in 30 rats given 1-2 ml MNNG dissolved in distilled water (5 mg/ml) through a gastric tube for 2-3 days. The procedure is repeated every 4-10 days. This intermittent carcinogen administration continued until week 20; the animals were killed on week 25. All effective 26 (100%) rats had multiple papillomas and squamous cell carcinomas of the forestomach, 5 (19.2%) had adenomatous hyperplasias and adenocarcinomas of the glandular stomach, 7 (26.9%) had adenocarcinomas and sarcomas of the small intestine.
通过胃管给30只大鼠经胃管注入溶解于蒸馏水中的1 - 2毫升N - 甲基 - N'- 硝基 - N - 亚硝基胍（5毫克/毫升），持续2 - 3天，研究了其对大鼠致癌作用的特点。该操作每4 - 10天重复一次。这种间歇性给予致癌物的操作持续到第20周；动物在第25周处死。所有26只（100%）有效大鼠均有前胃多发性乳头状瘤和鳞状细胞癌，5只（19.2%）有腺胃腺瘤样增生和腺癌，7只（26.9%）有小肠腺癌和肉瘤。
