Okere P C N, Olusina D B, Shamim S A, Shandra V, Tushar M, Sellam K, Bal C
Department of Radiation Medicine and Department of Morbid Anatomy, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria.
Niger J Clin Pract. 2013 Jan-Mar;16(1):96-9. doi: 10.4103/1119-3077.106775.
Many factors, including relatively young age of thyroid cancer diagnoses and improved survival, have led to increased concerns about the occurrence of second primary malignancies. This paper describes the pattern of occurrence of second primary malignancies in patients who were treated for malignant thyroid neoplasms in an Indian hospital. There were 21 affected patients of the approximately 4500 seen over 25 years. Most of the second primary cancers are solid tumors, and when nonthyroid cancers are the second tumors, ductal carcinoma of the female breast is the most common. Most of these tumors have very short detection intervals (including synchronous occurrences), suggesting that therapy with internal radiation was not contributory to the tumor development. When thyroid malignancies were the second primary cancers, they usually follow radiotherapy to the head and neck region for treatment of the first primary tumor and tend to be of aggressive histologic types than the common well differentiated thyroid carcinomas.
包括甲状腺癌诊断时相对年轻的年龄以及生存率提高等在内的诸多因素，引发了人们对第二原发性恶性肿瘤发生的更多关注。本文描述了一家印度医院中接受过恶性甲状腺肿瘤治疗的患者发生第二原发性恶性肿瘤的模式。在25年期间诊治的约4500例患者中有21例受影响。大多数第二原发性癌症为实体瘤，当第二肿瘤为非甲状腺癌时，女性乳腺癌的导管癌最为常见。这些肿瘤大多检测间隔很短（包括同时发生的情况），这表明内照射治疗与肿瘤发生无关。当甲状腺恶性肿瘤为第二原发性癌症时，它们通常继发于头颈部区域因治疗第一原发性肿瘤而进行的放疗之后，并且组织学类型往往比常见的高分化甲状腺癌更具侵袭性。
