Department of Radiology, National Center Hospital of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8551, Japan.
Jpn J Radiol. 2013 Apr;31(4):253-61. doi: 10.1007/s11604-012-0178-0. Epub 2013 Feb 2.
The purpose of this study was to examine the relationship between the volume and number of tubers and the age at seizure onset in patients with tuberous sclerosis complex. We also examined the relationship between the volume and number of cyst-like tubers and the age at seizure onset.
We retrospectively studied 23 patients with TSC (16 males and 7 females, mean age 12.4 ± 9.5 years). Routine structural MR-imaging data analysis was performed using QBrain. Total brain volume, total tuber volume, and the number of tubers were measured semi-automatically. Additionally, the total volume and the number of only cyst-like tubers were measured. The tuber/brain proportion (TBP) and the cyst-like tuber/brain proportion (cTBP) were calculated, and these were compared with the age at seizure onset. The numbers of tubers and cyst-like tubers were also compared with the age at seizure onset.
For both TBP and the number of tubers, a significant negative correlation with age at seizure onset was identified (ρ = -0.69, p < 0.01 and ρ = -0.56, p < 0.01). No significant correlation of cTBP or the number of cyst-like tubers with age at seizure onset was identified (ρ = -0.26, p = 0.37 and ρ = -0.048, p = 0.87).
TBP may be associated with age at seizure onset.
本研究旨在探讨结节性硬化症患者结节数量和体积与癫痫发作年龄之间的关系。我们还研究了囊状结节的数量和体积与癫痫发作年龄之间的关系。
我们回顾性研究了 23 例 TSC 患者（男 16 例，女 7 例，平均年龄 12.4 ± 9.5 岁）。使用 QBrain 对常规结构 MRI 数据进行分析。半自动化测量全脑体积、总结节体积和结节数量。此外，还测量了仅囊状结节的总体积和数量。计算了结节/脑比例（TBP）和囊状结节/脑比例（cTBP），并将其与癫痫发作年龄进行比较。还比较了结节和囊状结节的数量与癫痫发作年龄的关系。
TBP 和结节数量均与癫痫发作年龄呈显著负相关（ρ=-0.69，p<0.01 和 ρ=-0.56，p<0.01）。囊状结节的 cTBP 或数量与癫痫发作年龄无显著相关性（ρ=-0.26，p=0.37 和 ρ=-0.048，p=0.87）。
TBP 可能与癫痫发作年龄有关。
