Department of Diagnostic Services - O.U. Laboratory Analysis of Clinical Chemistry and Microbiology, S. Maria della Scaletta Hospital, Imola, Bologna, Italy.
Eur Rev Med Pharmacol Sci. 2013 Jan;17(2):206-9.
For frequency Escherichia (E.) coli is the agent of urinary tract infections (UTIs). The objective of the present study was to evaluate in vitro activity of several antimicrobial agents to guide empirical treatment of uncomplicated UTIs. In vitro antimicrobial susceptibility of 429 E. coli strains, isolated in urine specimens from community-acquired uncomplicated UTIs in outpatients, was studied during the 1st semester 2011.
Urine samples were processed with Robobact/Uriset system. E. coli strains were identified with GN card for VITEK-2 system and API 20E gallery, as confirmatory assay. E. coli strains were tested, for antimicrobial susceptibility, using VITEK-2 system and confirmed with disk diffusion method.
Penicillins have exhibited sensitivity percentage of 50.9%, inhibitor-protected penicillins 88.9%, cephalosporins 91.6%, carbapenem 100%, aminoglycosides 91.5%, fluoroquinolones 71.8%, nitrofuran 99.3% and sulfonamide 74.1%.
In vitro imipenem, nitrofurantoin, cephalosporins and aminoglycosides (>90% of isolates) have the best sensitivity in community-acquired UTIs. In particular nitrofurantoin has showed a low MIC distribution and high sensitivity percentage. Therefore, could be suggested in empirical treatment of these infections.
大肠埃希菌（E. coli）是尿路感染（UTIs）的常见病原体。本研究旨在评估几种抗菌药物的体外活性，以指导经验性治疗单纯性尿路感染。
对 2011 年第 1 学期从社区获得性单纯性尿路感染门诊患者尿液标本中分离的 429 株大肠埃希菌进行体外抗菌药敏试验。采用 Robobact/Uriset 系统处理尿液样本。采用 VITEK-2 系统 GN 卡和 API 20E 图库对大肠埃希菌进行鉴定，作为确证试验。采用 VITEK-2 系统和纸片扩散法对大肠埃希菌进行抗菌药敏试验。
青霉素类药物的敏感性百分比为 50.9%，含抑制剂保护的青霉素类药物为 88.9%，头孢菌素类药物为 91.6%，碳青霉烯类药物为 100%，氨基糖苷类药物为 91.5%，氟喹诺酮类药物为 71.8%，硝基呋喃类药物为 99.3%，磺胺类药物为 74.1%。
在社区获得性 UTIs 中，体外亚胺培南、呋喃妥因、头孢菌素类和氨基糖苷类药物（>90%的分离株）具有最佳敏感性。特别是呋喃妥因表现出较低的 MIC 分布和较高的敏感性百分比。因此，可建议在这些感染的经验性治疗中使用。
