Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology Toxicology, Saarland University, D-66421, Homburg (Saar), Germany.
J Mass Spectrom. 2013 Feb;48(2):243-9. doi: 10.1002/jms.3142.
In the last years, the number of new psychoactive substances, so-called 'legal highs', has enormously increased. They are sold via online shops often with inaccurate and false information about the content. The aim of this work was to study the metabolism and the detectability of the drug of abuse diphenyl-2-pyrrolidinemethanol (D2PM) in rat urine using gas chromatography-mass spectrometry and liquid chromatography-high resolution-tandem mass spectrometry. Five phase I and two phase II metabolites were identified suggesting hydroxylation at the pyrrolidine and diphenyl part as the main metabolic steps. Assuming similar kinetics, an intake of D2PM should be detectable in human urine mainly via its metabolites.
在过去的几年中，新精神活性物质（所谓的“合法兴奋剂”）的数量大幅增加。它们通过网店销售，有关含量的信息往往不准确和虚假。本工作的目的是使用气相色谱-质谱联用仪和液相色谱-高分辨串联质谱法研究滥用药物二苯-2-吡咯烷甲醇（D2PM）在大鼠尿液中的代谢和可检测性。鉴定出五个 I 相代谢物和两个 II 相代谢物，提示吡咯烷和二苯部分的羟化是主要的代谢步骤。假设类似的动力学，D2PM 的摄入应该可以主要通过其代谢物在人尿中检测到。
