Department of Ophthalmology, Royal Bolton Hospital Foundation Trust, Bolton, BL4 0JR, UK,
J Thromb Thrombolysis. 2013 Oct;36(3):343-5. doi: 10.1007/s11239-013-0877-0.
To report a case of bilateral spontaneous hyphaema in a patient on warfarin sodium for atrial fibrillation and COPD. A case report and literature review. A 76-year-old man presented with bilateral spontaneous hyphaema. There was no anterior chamber pathology known to predispose for spontaneous bleeding except for a history of paroxysmal atrial fibrillation treated with a daily dose of 3 mg of warfarin sodium. In addition, he was also suffering from severe COPD and was on oxygen supplementation. This is a rare case of a bilateral spontaneous hyphaema. Although the patient was on warfarin sodium, his INR was only 2.6 at the onset of his symptoms. It may be possible that the combined action of anti-coagulant properties of warfarin sodium and hypoxic vasodilatation of iris vessels may be responsible for bilateral hyphaema in this case.
报告 1 例华法林钠抗凝治疗的心房颤动合并 COPD 患者发生双侧自发性前房积血。病例报告及文献复习。1 例 76 岁男性，双侧自发性前房积血。除阵发性心房颤动病史外，无已知易导致自发性出血的前房病理学改变，该患者接受 3mg 华法林钠每日治疗。此外，他还患有严重的 COPD，并接受氧气补充治疗。这是 1 例罕见的双侧自发性前房积血。尽管患者正在服用华法林钠，但他在出现症状时的 INR 仅为 2.6。华法林钠的抗凝作用和虹膜血管缺氧性扩张可能共同导致了这种情况下的双侧前房积血。
