正常甲状腺功能和甲状腺功能减退的鸡胚（家鸡）中的脂质和碳水化合物代谢

Lipid and carbohydrate metabolism in euthyroid and hypothyroid chick embryo (Gallus domesticus).

Raheja K L, Linscheer W G

Department of Pharmacology, Veterans Administration Medical Center, Syracuse, NY.

Comp Biochem Physiol B. 1979;64(3):289-91. doi: 10.1016/0305-0491(79)90145-7.

Abstract

The effect of propylthiouracil (PTU)-induced hypothyroidism on carbohydrate and lipid metabolism was studied in the chick embryo. 2. A single dose of PTU (250 micrograms/embryo) was administered on day 11 and embryos sacrificed on day 20 of incubation. 3. Thyroid glands were significantly enlarged (6 fold) by PTU administration. 4. Increased thyroid weight was associated with growth retardation and decreased plasma thyroxine levels. 5. Plasma glucose level was lower and phospholipids were significantly higher in the hypothyroid embryo. 6. Liver lipid concentrations in the control and hypothyroid embryos were not different but were significantly higher in both groups when compared to previously reported values in the young chick. 7. In contrast to PTU treatment after hatching, liver glycogen levels were not increased in the hypothyroid chick embryo. This was attributed to the high lipid nutrient condition of the chick embryo since a high lipid diet in the young chick decreased hepatic glycogen accumulation significantly.

摘要

研究了丙硫氧嘧啶（PTU）诱导的甲状腺功能减退对鸡胚碳水化合物和脂质代谢的影响。2. 在孵化第11天给予单剂量的PTU（250微克/胚胎），并在孵化第20天处死胚胎。3. 给予PTU后甲状腺显著肿大（6倍）。4. 甲状腺重量增加与生长迟缓及血浆甲状腺素水平降低有关。5. 甲状腺功能减退的胚胎血浆葡萄糖水平较低，磷脂水平显著较高。6. 对照和甲状腺功能减退胚胎的肝脏脂质浓度无差异，但与先前报道的幼雏值相比，两组均显著较高。7. 与孵化后PTU治疗不同，甲状腺功能减退的鸡胚肝脏糖原水平未升高。这归因于鸡胚的高脂营养状况，因为幼雏的高脂饮食显著降低了肝脏糖原积累。