Zarcone V P, Hoddes E
Department of Psychiatry, Stanford University, Calif. 94305.
Am J Psychiatry. 1975 Jan;132(1):74-6. doi: 10.1176/ajp.132.1.74.
The authors studied the effects of oral loading with 5-HTP on REM fragmentation in a group of alcoholics who were abstinent following acute ethanol withdrawal. Decreased fragmentation was found in the majority of subjects, and those subjects with low baseline REM efficiency (i.e., greater fragmentation) showed more improvement from the drug than did subjects who were less impaired initially. The authors suggest that there is an organic decrement of serotonin during ethanol withdrawal which is partially reversed by 5-HTP loading.
作者研究了口服5-羟色氨酸负荷对一组急性乙醇戒断后已戒酒的酗酒者快速眼动睡眠片段化的影响。大多数受试者的睡眠片段化情况有所减轻，那些基线快速眼动睡眠效率较低（即片段化程度较高）的受试者从药物中获得的改善比最初受损较轻的受试者更多。作者认为，乙醇戒断期间血清素存在器质性减少，而5-羟色氨酸负荷可部分逆转这种减少。
