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利用聚焦超声实现脑内无创靶向药物递送。

Noninvasive and targeted drug delivery to the brain using focused ultrasound.

机构信息

Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.

出版信息

ACS Chem Neurosci. 2013 Apr 17;4(4):519-26. doi: 10.1021/cn300191b. Epub 2013 Feb 4.

DOI:10.1021/cn300191b
PMID:23379618
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3629738/
Abstract

Brain diseases are notoriously difficult to treat due to the presence of the blood-brain barrier (BBB). Here, we review the development of focused ultrasound (FUS) as a noninvasive method for BBB disruption, aiding in drug delivery to the brain. FUS can be applied through the skull to a targeted region in the brain. When combined with microbubbles, FUS causes localized and reversible disruption of the BBB. The cellular mechanisms of BBB disruption are presented. Several therapeutic agents have been delivered to the brain resulting in significant improvements in pathology in models of glioblastoma and Alzheimer's disease. The requirements for clinical translation of FUS will be discussed.

摘要

脑部疾病由于血脑屏障（BBB）的存在而难以治疗。在这里，我们回顾了聚焦超声（FUS）作为一种非侵入性的 BBB 破坏方法的发展，有助于将药物递送到大脑。FUS 可以通过颅骨应用于大脑中的靶向区域。当与微泡结合时，FUS 会导致 BBB 的局部和可逆性破坏。介绍了 BBB 破坏的细胞机制。已经将几种治疗剂递送到大脑中，导致胶质母细胞瘤和阿尔茨海默病模型中的病理显著改善。将讨论 FUS 临床转化的要求。

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本文引用的文献

[1]
Focused ultrasound delivers targeted immune cells to metastatic brain tumors.

Cancer Res. 2013-1-9

[2]
Ultrasound-mediated blood-brain/blood-tumor barrier disruption improves outcomes with trastuzumab in a breast cancer brain metastasis model.

J Control Release. 2012-9-18

[3]
Drug transport across the blood-brain barrier.

J Cereb Blood Flow Metab. 2012-8-29

[4]
Focused ultrasound for targeted delivery of siRNA and efficient knockdown of Htt expression.

J Control Release. 2012-8-19

[5]
Targeted delivery of self-complementary adeno-associated virus serotype 9 to the brain, using magnetic resonance imaging-guided focused ultrasound.

Hum Gene Ther. 2012-10-15

[6]
Improved anti-tumor effect of liposomal doxorubicin after targeted blood-brain barrier disruption by MRI-guided focused ultrasound in rat glioma.

Ultrasound Med Biol. 2012-7-19

[7]
Ultrasound enhanced drug delivery to the brain and central nervous system.

Int J Hyperthermia. 2012

[8]
Temporary disruption of the blood-brain barrier by use of ultrasound and microbubbles: safety and efficacy evaluation in rhesus macaques.

Cancer Res. 2012-5-2

[9]
Low-frequency ultrasound irradiation increases blood-tumor barrier permeability by transcellular pathway in a rat glioma model.

J Mol Neurosci. 2012-4-20

[10]
Blood-brain barrier: real-time feedback-controlled focused ultrasound disruption by using an acoustic emissions-based controller.

Radiology. 2012-2-13

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