聚焦超声诱导血脑屏障开放的安全性和有效性：动物和人体研究的综合评价。
Safety and efficacy of focused ultrasound induced blood-brain barrier opening, an integrative review of animal and human studies.
机构信息
Division of Neurosurgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada; Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.
Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.
出版信息
J Control Release. 2019 Sep 10;309:25-36. doi: 10.1016/j.jconrel.2019.07.023. Epub 2019 Jul 18.
The blood-brain barrier, while fundamental in maintaining homeostasis in the central nervous system, is a bottleneck to achieving efficacy for numerous therapeutics. Improved brain penetration is also desirable for reduced dose, cost, and systemic side effects. Transient disruption of the blood-brain barrier with focused ultrasound (FUS) can facilitate drug delivery noninvasively with precise spatial and temporal specificity. FUS technology is transcranial and effective without further drug modifications, key advantages that will accelerate adoption and translation of existing therapeutic pipelines. In this review, we performed a comprehensive literature search to build a database and provide a synthesis of ultrasound parameters and drug characteristics that influence the safety and efficacy profile of FUS to enhance drug delivery.
血脑屏障在维持中枢神经系统内环境稳定方面起着至关重要的作用，但它也成为了许多治疗药物难以发挥疗效的瓶颈。为了降低剂量、成本和减少全身副作用，提高药物向脑部的渗透也是人们所期望的。利用聚焦超声（FUS）短暂破坏血脑屏障，可以实现药物的非侵入性精准传递，具有精确的空间和时间特异性。FUS 技术无需进一步的药物修饰即可实现经颅传递，这是其关键优势，将加速现有治疗药物研发管线的采用和转化。在本综述中，我们进行了全面的文献检索，构建了一个数据库，并对影响 FUS 增强药物递送的安全性和疗效的超声参数和药物特性进行了综合分析。
Zotero 插件