Yeragani V K, Meiri P, Balon R, Pohl R, Golec S
Wayne State University, School of Medicine, Department of Psychiatry, Detroit, MI 48207.
Eur J Clin Pharmacol. 1990;38(2):139-44. doi: 10.1007/BF00265972.
Postural and isometric handgrip tests were performed on nine patients with panic disorder and 13 patients with major depression before and after treatment with imipramine for a mean duration of 10 weeks. There were significant increases in resting supine heart rate (HR), systolic, diastolic and mean blood pressures (SBP, DBP, MBP) after treatment. There were significant increases in HR and DBP after standing from supine posture before treatment, and after treatment, there was a significant enhancement of this tachycardia. The decrease of heart rate during the change from standing to supine posture before treatment significantly decreased further after imipramine treatment. Decreases in SBP and DBP during the change from standing to supine posture were significantly smaller during the post treatment condition. Increases in SBP during the standing isometric exercise test were smaller after treatment. These findings suggest abnormal orthostatic reflexes secondary to an altered adrenergic function and/or cholinergic supersensitivity after treatment with imipramine.
对9名惊恐障碍患者和13名重度抑郁症患者在接受平均为期10周的丙咪嗪治疗前后进行了姿势和等长握力测试。治疗后静息仰卧心率（HR）、收缩压、舒张压和平均血压（SBP、DBP、MBP）显著升高。治疗前从仰卧姿势站立后HR和DBP显著升高，治疗后这种心动过速显著增强。治疗前从站立姿势变为仰卧姿势时心率的下降在丙咪嗪治疗后进一步显著降低。治疗后从站立姿势变为仰卧姿势时SBP和DBP的下降显著更小。站立等长运动测试期间SBP的升高在治疗后更小。这些发现表明，丙咪嗪治疗后，由于肾上腺素能功能改变和/或胆碱能超敏反应继发体位性反射异常。
