Krause John R, Drinkard Lee C, Keglovits Latoya C
Section of Hematopathology. Department of Pathology, Baylor University Medical Center at Dallas, Dallas, Texas (Krause, Keglovits); and Metroplex Cancer Specialists, Keller, Texas (Drinkard).
Proc (Bayl Univ Med Cent). 2013 Jan;26(1):16-8. doi: 10.1080/08998280.2013.11928901.
Transformation to a large cell lymphoma may occur during the course of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) in approximately 5% of the cases. This is known as Richter's transformation. A much less frequent transformation to Hodgkin lymphoma may occur. We report a case of CLL/SLL in which a transformation to Hodgkin lymphoma occurred, and we review previously published reports of this transformation. Transformation to Hodgkin lymphoma in CLL/SLL has a poor outcome compared to de novo cases of Hodgkin lymphoma.
在慢性淋巴细胞白血病/小淋巴细胞淋巴瘤（CLL/SLL）病程中，约5%的病例可能会转化为大细胞淋巴瘤。这被称为里氏转化。转化为霍奇金淋巴瘤的情况则更为少见。我们报告了一例CLL/SLL转化为霍奇金淋巴瘤的病例，并回顾了此前发表的关于这种转化的报告。与原发性霍奇金淋巴瘤病例相比，CLL/SLL转化为霍奇金淋巴瘤的预后较差。
