Yamakami Shinji, Mikami Yumiko, Watanabe Kazuko, Saya Yoshiko, Tanaka Chie, Eto Hikaru, Takeda Kyoko
Clinical Laboratory Department, St. Luke's International Hospital, Chuo-ku, Tokyo 104-8560, Japan.
Rinsho Byori. 2012 Nov;60(11):1040-4.
Mycoplasma hominis is a common inhabitant of the human urogenital tract and most frequently causes diseases of the genitourinary tract. Extragenital M. hominis infections are uncommon, with almost all occurring in immunosuppressed persons or those predisposed due to surgery or trauma. We report a case of non surgical, non-traumatic wound infection caused by M. hominis. A 28-year-old immunocompetent woman with livedo vasculopathy had an open wound on dorsum of her right foot with signs and symptoms of infection. However, gram staining of the wound swab demonstrated no microorganisms, and initial bacterial cultures did not reveal any microbial growth. After 2 days of culture, minute translucent colonies were appeared and subsequently identified as M. hominis. She was successfully treated with levofloxacin(LVFX). For the patient's being immune-competent, this infection seems to need a substantial bacterial transfer from the inhabitant organ. The transfer is likely mediated by the fluid's drop, for anatomical locations of vagina and the infection site on leg. Namely, the hinder leg infection is suspected to be caused by continual and heavy bacterial exposure originated from the vaginal M. hominis. This clinical case suggests that infections may occur even in normal immunological status if the site is close to, and lacks anatomical barrier from, the M. hominis inhabitant organ. Especially in infection at chronic refractory lower leg ulceraion, M. hominis should be considered as a causative organism.
人型支原体是人类泌尿生殖道的常见寄居菌,最常引起泌尿生殖道疾病。人型支原体的生殖器外感染并不常见,几乎所有感染都发生在免疫抑制人群或因手术或创伤而易感的人群中。我们报告一例由人型支原体引起的非手术、非创伤性伤口感染病例。一名患有青斑血管病的28岁免疫功能正常女性,右脚背部有一个开放性伤口,伴有感染的体征和症状。然而,伤口拭子的革兰氏染色未显示微生物,初始细菌培养也未发现任何微生物生长。培养2天后,出现微小的半透明菌落,随后鉴定为人型支原体。她接受左氧氟沙星(LVFX)治疗成功。对于该免疫功能正常的患者,这种感染似乎需要大量细菌从寄居器官转移。这种转移可能是由液滴介导的,因为阴道和腿部感染部位的解剖位置。也就是说,怀疑后腿感染是由源自阴道人型支原体的持续大量细菌暴露引起的。该临床病例表明,如果感染部位靠近人型支原体寄居器官且缺乏解剖屏障,即使在正常免疫状态下也可能发生感染。特别是在慢性难治性小腿溃疡感染中,应考虑人型支原体作为病原体。