Bozkurt A, Basci N E, Isimer A, Tuncer M, Erdal R, Kayaalp S O
Department of Pharmacology, University of Hacettepe, Ankara, Turkey.
Int J Clin Pharmacol Ther Toxicol. 1990 Apr;28(4):164-6.
Acetylation of sulphamethoxazole was studied in 22 subjects previously phenotyped with sulphadimidine. Sulphamethoxazole and its acetylated metabolite were measured in 6 h plasma and 0-6 h urine samples. Percentage of plasma acetylated-sulphamethoxazole did not correlate with the percentage of urinary acetylated-sulphamethoxazole. There was also no correlation between the percentage of acetylated-sulphadimidine and percentage of acetylated-sulphamethoxazole in plasma. The finding suggest that the acetylation of sulphamethoxazole has no predictive value in determining acetylator status.
在22名先前已用磺胺二甲嘧啶进行表型分型的受试者中研究了磺胺甲恶唑的乙酰化情况。在6小时血浆和0 - 6小时尿液样本中测定了磺胺甲恶唑及其乙酰化代谢产物。血浆中乙酰化磺胺甲恶唑的百分比与尿液中乙酰化磺胺甲恶唑的百分比不相关。血浆中乙酰化磺胺二甲嘧啶的百分比与乙酰化磺胺甲恶唑的百分比之间也没有相关性。这些发现表明，磺胺甲恶唑的乙酰化在确定乙酰化状态方面没有预测价值。
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