Rampen F H, van der Meeren H L, Stolk L M
Acta Derm Venereol. 1986;66(4):334-6.
The relationship of acetylation phenotype to skin complexion was studied in 155 healthy Caucasians. Individuals received 500 mg sulphadimidine at 11.00 p.m.; urine was collected eight hours later. The percentage of acetylated sulphadimidine in urine was measured with high performance liquid chromatography. There was a slight but insignificant preponderance of slow acetylators in the dark skin types. It is concluded that slow acetylation phenotype is not correlated with light skin complexion. Therefore, it is unlikely that acetylation of xenobiotic carcinogens plays a dominant role in melanoma risk.
在155名健康白种人中研究了乙酰化表型与肤色的关系。研究对象于晚上11点服用500毫克磺胺二甲嘧啶；8小时后收集尿液。采用高效液相色谱法测定尿液中乙酰化磺胺二甲嘧啶的百分比。在深色皮肤类型中，慢乙酰化者略有优势，但无统计学意义。研究得出结论，慢乙酰化表型与浅肤色无关。因此，外源性致癌物的乙酰化在黑色素瘤风险中不太可能起主导作用。
