Neuroscience Research Australia, Sydney, Australia.
Amyotroph Lateral Scler Frontotemporal Degener. 2013 Apr;14(3):169-71. doi: 10.3109/21678421.2013.764899. Epub 2013 Feb 5.
ALS and frontotemporal dementia (FTD) utilize different functional rating scales: the ALSFRS-R assesses physical disability whereas the Frontotemporal Dementia Rating Scale assesses behavioural and functional impairment to produce an index of dementia staging. To better consider the applicability of the FRS in an ALS population, 130 patient-carer dyads were investigated. Scores on the ALSFRS-R and FRS were not significantly correlated (r(s) = 0.12, p > 0.10). Furthermore, patients with mild physical disability may rate as severe on the FRS; conversely, individuals who are severely physically disabled may exhibit very few behavioural symptoms. Measures typically used in ALS studies do not fully encapsulate the range of clinical symptoms, particularly from a behavioural perspective.
肌萎缩侧索硬化症（ALS）和额颞叶痴呆（FTD）使用不同的功能评定量表：ALSFRS-R 评估身体残疾，而额颞叶痴呆评定量表评估行为和功能障碍，以产生痴呆分期指数。为了更好地考虑 FRS 在 ALS 人群中的适用性，研究了 130 对患者-照顾者对。ALSFRS-R 和 FRS 的评分没有显著相关性（r(s) = 0.12，p > 0.10）。此外，轻度身体残疾的患者可能在 FRS 上评为严重；相反，身体严重残疾的个体可能表现出很少的行为症状。ALS 研究中常用的措施并不能完全包含临床症状的范围，特别是从行为角度来看。
