Peaker M, Taylor E
Hannah Research Institute, Ayr.
J Endocrinol. 1990 Apr;125(1):R1-3. doi: 10.1677/joe.0.125r001.
Mammary tissue from goats had significantly higher aromatase activity at 148-149 days of pregnancy than earlier in pregnancy or during lactation. Aromatase activity was determined by production of 3H2O from [1 beta-3H]androstenedione that was inhibited by 4-hydroxyandrostenedione. The time of maximum aromatization was during peak mammary output of oestradiol-17 beta described previously in vivo in the same species. Aromatase activity in the mouse mammary gland was low and no peak was observed in late pregnancy. It is concluded that the oestrogens produced by the mammary gland in the late-pregnant goat are formed by aromatization of androgens.
山羊乳腺组织在妊娠148 - 149天时的芳香化酶活性显著高于妊娠早期或哺乳期。芳香化酶活性通过[1β - 3H]雄烯二酮生成3H2O来测定，该反应受到4 - 羟基雄烯二酮的抑制。最大芳香化作用的时间与先前在同一物种体内所描述的雌二醇 - 17β乳腺分泌高峰期一致。小鼠乳腺中的芳香化酶活性较低，在妊娠后期未观察到活性峰值。研究得出结论，妊娠后期山羊乳腺产生的雌激素是由雄激素的芳香化作用形成的。
