Johns Hopkins University, Baltimore, MD, USA.
Invest Radiol. 2013 Apr;48(4):223-30. doi: 10.1097/RLI.0b013e318281057d.
The aim of this study was to evaluate the quantitative and semiquantitative measures of regional pulmonary parenchymal perfusion in patients with chronic obstructive pulmonary disease (COPD) in relationship to global lung perfusion (GLP) and lung diffusing capacity (DLCO).
A total of 143 participants in the Multiethnic Study of Atherosclerosis COPD Study were examined by dynamic contrast-enhanced pulmonary perfusion magnetic resonance imaging (MRI) at 1.5 T. Pulmonary microvascular blood flow (PBF) was calculated on a pixel-by-pixel basis by using a dual-bolus technique and the Fermi function model. Semiquantitative parameters for regional pulmonary microvascular perfusion were calculated from signal intensity-time curves in the lung parenchyma. Intraoberserver and interobserver coefficients of variation (CVs) and correlations between quantitative and semiquantitative MRI parameters and with GLP and DLCO were determined.
Quantitative and semiquantitative parameters of pulmonary microvascular perfusion were reproducible, with CVs for all parameters of less than 10%. Furthermore, these MRI parameters were correlated with GLP and DLCO, and there was good agreement between PBF and GLP. Quantitative and semiquantitative MRI parameters were closely correlated (eg, r = 0.86 for maximum signal increase with PBF). In participants without COPD, the physiological distribution of pulmonary perfusion could be determined by regional MRI measurements.
Regional pulmonary microvascular perfusion can reliably be quantified from dynamic contrast-enhanced MRI. Magnetic resonance imaging-derived quantitative and semiquantitative perfusion measures correlate with GLP and DLCO.
本研究旨在评估慢性阻塞性肺疾病（COPD）患者肺部实质区域性灌注的定量和半定量指标与整体肺灌注（GLP）和肺弥散量（DLCO）的关系。
共对多民族动脉粥样硬化研究中的 COPD 研究的 143 名参与者进行了 1.5T 动态对比增强肺部灌注磁共振成像（MRI）检查。通过双脉冲技术和费米函数模型对肺部微血管血流（PBF）进行逐像素计算。从肺部实质的信号强度-时间曲线计算区域性肺部微血管灌注的半定量参数。确定了定量和半定量 MRI 参数的观察者内和观察者间变异系数（CV）以及与 GLP 和 DLCO 的相关性。
肺部微血管灌注的定量和半定量参数具有可重复性，所有参数的 CV 均小于 10%。此外，这些 MRI 参数与 GLP 和 DLCO 相关，并且 PBF 与 GLP 之间具有良好的一致性。定量和半定量 MRI 参数密切相关（例如，与 PBF 相比，最大信号增加的 r 值为 0.86）。在没有 COPD 的参与者中，可以通过区域 MRI 测量确定肺部灌注的生理分布。
可以从动态对比增强 MRI 可靠地定量区域性肺部微血管灌注。磁共振成像衍生的定量和半定量灌注指标与 GLP 和 DLCO 相关。
