Natl Toxicol Program Tech Rep Ser. 2012 Dec(576):1-144.
Trimethylolpropane triacrylate (TMPTA) is used as an ingredient in a wide variety of coatings, resins, photosensitive materials, and superabsorbent baby diapers. We studied the effects of TMPTA on male and female rats and mice to identify potential toxic or cancer-related hazards.
We applied solutions containing TMPTA in acetone on the backs of male and female rats and mice. Groups of 50 male and female rats and mice received 0.3, 1, or 3 milligrams of TMPTA per kilogram of body weight five days per week for two years. Groups of animals receiving acetone alone served as the control groups. At the end of the study, tissues from more than 40 sites were examined for every animal.
Survival and body weights of all groups of exposed animals were similar to the control groups. Epidermal hyperplasia was observed in the skin at the site where the chemical was applied in all groups of animals receiving 1 mg/kg or more. Hyperkeratosis at the site of application was also increased in rats receiving TMPTA, and chronic inflammation was also seen in the skin of male and female mice receiving TMPTA. Malignant mesotheliomas were seen in a few male rats exposed to TMPTA. Two different rare forms of liver cancer (hepatoblastoma and hepatocholangiocarcinoma) were observed in some of the female mice exposed to TMPTA, and tumors of the uterus (stromal polyp or stromal sarcoma) also occurred in some exposed female mice.
We conclude that exposure to TMPTA caused rare cancers of the liver and tumors of the uterus in female mice and may have been related to the occurrence of malignant mesothelioma in male rats. No occurrences of cancer were associated with exposure to TMPTA in female rats or male mice. Skin lesions at the site of application, including hyperplasia in rats and mice, hyperkeratosis in rats, and inflammation in mice occurred in all animal groups exposed to higher concentrations of TMPTA.
三羟甲基丙烷三丙烯酸酯（TMPTA）被用作多种涂料、树脂、感光材料和高吸水性婴儿尿布的一种成分。我们研究了TMPTA对雄性和雌性大鼠及小鼠的影响，以确定潜在的毒性或癌症相关危害。
我们将含有TMPTA的丙酮溶液涂抹在雄性和雌性大鼠及小鼠的背部。每组50只雄性和雌性大鼠及小鼠，每周5天，持续两年，给予每千克体重0.3、1或3毫克的TMPTA。仅接受丙酮的动物组作为对照组。在研究结束时，对每只动物超过40个部位的组织进行了检查。
所有暴露动物组的存活率和体重与对照组相似。在接受1毫克/千克或更高剂量的所有动物组中，在涂抹化学品的部位皮肤出现了表皮增生。接受TMPTA的大鼠在涂抹部位的角化过度也有所增加，接受TMPTA的雄性和雌性小鼠的皮肤也出现了慢性炎症。在一些暴露于TMPTA的雄性大鼠中发现了恶性间皮瘤。在一些暴露于TMPTA的雌性小鼠中观察到两种不同的罕见肝癌形式（肝母细胞瘤和肝内胆管癌），一些暴露的雌性小鼠还出现了子宫肿瘤（间质息肉或间质肉瘤）。
我们得出结论，暴露于TMPTA会导致雌性小鼠出现罕见的肝癌和子宫肿瘤，可能与雄性大鼠恶性间皮瘤的发生有关。雌性大鼠或雄性小鼠暴露于TMPTA未出现癌症。在所有暴露于较高浓度TMPTA的动物组中，涂抹部位出现了皮肤病变，包括大鼠和小鼠的增生、大鼠的角化过度以及小鼠的炎症。
