Semafuko W E, Morris D J
Department of Pathology and Laboratory Medicine, Miriam Hospital, Providence, RI 02906.
J Hum Hypertens. 1990 Apr;4(2):165-7.
The present investigation was designed to study the effect of high calcium diet and nitrendipine on aldosterone-induced development of high blood pressure in young adrenalectomised spontaneously hypertensive rats (SHR). Animals raised on a control calcium diet (0.5% Ca) or high calcium diet (2.5% Ca) were adrenalectomised aged 5-6 weeks and treated with either aldosterone (1 microgram/day subcutaneously) in propylene glycol or aldosterone (1 microgram/day) plus nitrendipine (20 mg/kg/48 hr subcutaneously) in peanut oil. Controls received the aldosterone or nitrendipine vehicle and treatment lasted two weeks. The animals were given 0.9% NaCl ad libitum. Aldosterone caused a significant increase in systolic BP in adrenalectomised SHR fed the control calcium diet when compared with controls and the aldosterone-induced hypertension was blocked by the high calcium diet and nitrendipine (P less than 0.001, n = 4-7). These findings suggest that high dietary calcium has a protective effect against the development of aldosterone-induced hypertension and may enhance that of nitrendipine.
本研究旨在探讨高钙饮食和尼群地平对年轻去肾上腺自发性高血压大鼠（SHR）醛固酮诱导的高血压发展的影响。将5 - 6周龄的动物饲养在对照钙饮食（0.5%钙）或高钙饮食（2.5%钙）中，然后进行去肾上腺手术，并分别用丙二醇中的醛固酮（1微克/天皮下注射）或花生油中的醛固酮（1微克/天）加尼群地平（20毫克/千克/48小时皮下注射）进行处理。对照组接受醛固酮或尼群地平的赋形剂，处理持续两周。动物自由饮用0.9%氯化钠溶液。与对照组相比，给予对照钙饮食的去肾上腺SHR中，醛固酮导致收缩压显著升高，而高钙饮食和尼群地平可阻断醛固酮诱导的高血压（P < 0.001，n = 4 - 7）。这些发现表明，高钙饮食对醛固酮诱导的高血压发展具有保护作用，并且可能增强尼群地平的作用。
