Department of Molecular Cell Biology, Leiden University Medical Centre, 2333 ZC Leiden, The Netherlands.
Cold Spring Harb Perspect Biol. 2013 Mar 1;5(3):a013003. doi: 10.1101/cshperspect.a013003.
Adenoviruses have attracted much attention as probes to study biological processes such as DNA replication, transcription, splicing, and cellular transformation. More recently these viruses have been used as gene-transfer vectors and oncolytic agents. On the other hand, adenoviruses are notorious pathogens in people with compromised immune functions. This article will briefly summarize the basic replication strategy of adenoviruses and the key proteins involved and will deal with the new developments since 2006. In addition, we will cover the development of antivirals that interfere with human adenovirus (HAdV) replication and the impact of HAdV on human disease.
腺病毒作为研究生物过程(如 DNA 复制、转录、剪接和细胞转化)的探针引起了广泛关注。最近,这些病毒已被用作基因转移载体和溶瘤剂。另一方面,腺病毒在免疫功能受损的人群中是臭名昭著的病原体。本文将简要总结腺病毒的基本复制策略及其涉及的关键蛋白,并讨论 2006 年以来的新进展。此外,我们还将介绍干扰人腺病毒(HAdV)复制的抗病毒药物的开发以及 HAdV 对人类疾病的影响。