病毒免疫细胞毒性T细胞提供的抗病毒保护：在感染性病毒后代组装之前，被感染的靶细胞就会被裂解。
Antiviral protection by virus-immune cytotoxic T cells: infected target cells are lysed before infectious virus progeny is assembled.
作者信息
Zinkernagel R M, Althage A
机构信息
Department of Cellular and Developmental Immunology, Scripps Clinic and Research Foundation, La Jolla, California 92037.
出版信息
J Exp Med. 1977 Mar 1;145(3):644-51. doi: 10.1084/jem.145.3.644.
Abstract
Virus-immune cytotoxic T cells can inhibit effectively growth of vaccinia virus in acutely infected target cells in vitro by destroying infected target cells before infectious virus progeny is assembled. Together with the fact that virus-specific T cells are demonstrable after 3 days, very early during infection, and with strong circumstantial evidence from adoptive transfer models in vivo, these data suggest that in some virus infections T cells may in fact act cytolytically in vivo to prevent virus growth and spread and be an important early antiviral effector mechanism.
摘要
病毒免疫细胞毒性T细胞可通过在传染性病毒子代组装之前破坏被感染的靶细胞，在体外有效抑制痘苗病毒在急性感染靶细胞中的生长。鉴于病毒特异性T细胞在感染后3天即感染早期就可被检测到，以及体内过继转移模型提供的有力间接证据，这些数据表明，在某些病毒感染中，T细胞实际上可能在体内发挥溶细胞作用，以阻止病毒生长和传播，并且是一种重要的早期抗病毒效应机制。
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Cell-medicated cytotoxicity against ectromelia virus-infected target cells. III. Role of the H-2 gene complex.细胞介导的针对感染痘苗病毒的靶细胞的细胞毒性。III. H-2基因复合体的作用。
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