肥大细胞：抵抗细菌病原体的多面保护促进者。
Mast cells: multitalented facilitators of protection against bacterial pathogens.
机构信息
South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, San Antonio, TX 78249, USA.
出版信息
Expert Rev Clin Immunol. 2013 Feb;9(2):129-38. doi: 10.1586/eci.12.95.
Abstract
Mast cells are crucial effector cells evoking immune responses against bacterial pathogens. The positioning of mast cells at the host-environment interface, and the multitude of pathogen-recognition receptors and preformed mediator granules make these cells potentially the earliest to respond to an invading pathogen. In this review, the authors summarize the receptors used by mast cells to recognize invading bacteria and discuss the function of immune mediators released by mast cells in control of bacterial infection. The interaction of mast cells with other immune cells, including macrophages, dendritic cells and T cells, to induce protective immunity is highlighted. The authors also discuss mast cell-based vaccine strategies and the potential application in control of bacterial disease.
摘要
肥大细胞是引发针对细菌病原体免疫反应的关键效应细胞。由于其位于宿主与环境的交界处，并且具有多种病原体识别受体和预先形成的介质颗粒，这些细胞很可能是最早对入侵病原体作出反应的细胞。在这篇综述中，作者总结了肥大细胞识别入侵细菌所使用的受体，并讨论了肥大细胞释放的免疫介质在控制细菌感染中的功能。文章还强调了肥大细胞与其他免疫细胞（包括巨噬细胞、树突状细胞和 T 细胞）相互作用以诱导保护性免疫的作用。作者还讨论了基于肥大细胞的疫苗策略及其在控制细菌疾病方面的潜在应用。
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