β-CCE在自由或束缚状态的恒河猴（猕猴）中诱导产生的行为效应。

Behavioral effects induced by beta CCE in free or restrained rhesus monkeys (Macaca mulatta).

作者信息

Lagarde D, Laurent J, Milhaud C, Andre E, Aubin H J, Anton G

机构信息

Centre d'Etudes et de Recherches de Médecine Aérospatiale, Division de Neurophysiologie Appliquée, Paris, France.

出版信息

Pharmacol Biochem Behav. 1990 Mar;35(3):713-9. doi: 10.1016/0091-3057(90)90312-6.

DOI:10.1016/0091-3057(90)90312-6

PMID:2339160

Abstract

Behavioral effects of the IV injection of beta carboline carboxylic acid ethyl ester (beta CCE) were studied in chair-restrained rhesus monkeys and in rhesus monkeys freely moving in their cages. Observations made during the administration of increasing doses of beta CCE (0.5, 1 and 2 mg/kg) evidence behaviors reflecting a state of anxiety. The similarity of results obtained under the two experimental conditions excludes a potential effect of restraint on the behavioral expression of effects induced by the administered molecule. Convulsions observed in three subjects out of twelve should call for great caution when using this molecule.

摘要

在椅子束缚的恒河猴和在笼中自由活动的恒河猴身上研究了静脉注射β-咔啉羧酸乙酯（β-CCE）的行为效应。在给予递增剂量的β-CCE（0.5、1和2mg/kg）期间进行的观察表明，出现了反映焦虑状态的行为。在两种实验条件下获得的结果相似，排除了束缚对所给药分子诱导效应的行为表达的潜在影响。在12只受试动物中有3只出现惊厥，使用该分子时应格外谨慎。