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运用数学方法对药物从油包水型乳剂软膏中的释放进行研究。第4部分：厚层药物释放的动力学分析。

Studies on the release of drugs from O/W emulsion ointments using mathematical interpretations. Part 4: Kinetic analysis of drug release from thick layers.

作者信息

Bialik W

机构信息

Department of Applied Pharmacy and Drug Technology, Faculty of Pharmacy, Medical University School of Silesia, Sosnowiec, Poland.

出版信息

Pharmazie. 1990 Feb;45(2):119-20.

PMID:2339166
Abstract

A kinetic two-compartment model has been used in order to described drug release from thick layers of O/W emulsion ointments containing amphoteric surfactants as emulsifiers. It has been shown that the rate of release can be evaluated by the distribution coefficient of the drug between the compartments as accurately as by the use of effective diffusion coefficients.

摘要

为了描述含有两性表面活性剂作为乳化剂的O/W乳剂软膏厚层中的药物释放，采用了动力学双室模型。结果表明，通过药物在各室之间的分配系数评估释放速率与使用有效扩散系数评估一样准确。

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