生物钟对免疫系统的调控。
Circadian control of the immune system.
机构信息
Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
出版信息
Nat Rev Immunol. 2013 Mar;13(3):190-8. doi: 10.1038/nri3386. Epub 2013 Feb 8.
Abstract
Circadian rhythms, which have long been known to play crucial roles in physiology, are emerging as important regulators of specific immune functions. Circadian oscillations of immune mediators coincide with the activity of the immune system, possibly allowing the host to anticipate and handle microbial threats more efficiently. These oscillations may also help to promote tissue recovery and the clearance of potentially harmful cellular elements from the circulation. This Review summarizes the current knowledge of circadian rhythms in the immune system and provides an outlook on potential future implications.
摘要
昼夜节律长期以来一直被认为在生理学中起着至关重要的作用，现在正成为特定免疫功能的重要调节者。免疫介质的昼夜波动与免疫系统的活动相吻合，这可能使宿主能够更有效地预测和处理微生物威胁。这些波动还有助于促进组织恢复，并从循环中清除潜在的有害细胞成分。这篇综述总结了目前关于免疫系统昼夜节律的知识，并展望了未来的潜在影响。
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