Pawlak Zenon, Urbaniak Wiesław, Gadomski Adam, Yusuf Kehinde Q, Afara Isaac O, Oloyede Adekunle
Tribochemistry Consulting, Salt Lake City, UT 84117, USA.
Acta Bioeng Biomech. 2012;14(4):101-6.
This study aims to determine the effect of progressive loss of the surface active phospholipids on the characteristics, and hence tribological function of articular cartilage. In accordance to Hill's hypothesis, 3-7 lipid bilayers at pH 7.4 operate as the solid lubricant in the cartilage-cartilage interface during physiological function. These bilayers are known to be depleted during cartilage degeneration. This study models this loss of phospholipid bilayers, studying experimentally both wet and dry cartilage surfaces, measuring surface wettability, and friction coefficient under a constant stress of 1.2 MPa. The results demonstrate that the friction coefficient increases gradually with loss of the phospholipid bilayers, and gains in value with decrease in wettability.
本研究旨在确定表面活性磷脂的逐渐丧失对关节软骨特性及其摩擦学功能的影响。根据希尔假说，在生理功能期间，pH值为7.4时的3至7个脂质双层在软骨-软骨界面中充当固体润滑剂。已知这些双层在软骨退变过程中会减少。本研究对磷脂双层的这种丧失进行建模，通过实验研究湿软骨表面和干软骨表面，测量表面润湿性以及在1.2MPa恒定应力下的摩擦系数。结果表明，摩擦系数随着磷脂双层的丧失而逐渐增加，并随着润湿性的降低而增大。
