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Post-polyketide synthase steps in iso-migrastatin biosynthesis, featuring tailoring enzymes with broad substrate specificity.
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A Long-Range Acting Dehydratase Domain as the Missing Link for C17-Dehydration in Iso-Migrastatin Biosynthesis.
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Post-PKS tailoring steps of the spiramycin macrolactone ring in Streptomyces ambofaciens.
Antimicrob Agents Chemother. 2013 Aug;57(8):3836-42. doi: 10.1128/AAC.00512-13. Epub 2013 May 28.
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P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities.
Biochemistry. 2018 Aug 21;57(33):5005-5013. doi: 10.1021/acs.biochem.8b00623. Epub 2018 Aug 2.
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C-S bond cleavage by a polyketide synthase domain.
Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10359-64. doi: 10.1073/pnas.1508437112. Epub 2015 Aug 3.
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Titer improvement of iso-migrastatin in selected heterologous Streptomyces hosts and related analysis of mRNA expression by quantitative RT-PCR.
Appl Microbiol Biotechnol. 2011 Mar;89(6):1709-19. doi: 10.1007/s00253-010-3025-1. Epub 2010 Dec 4.

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Decoding human cytomegalovirus.
Science. 2012 Nov 23;338(6110):1088-93. doi: 10.1126/science.1227919.
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Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin.
Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15074-8. doi: 10.1073/pnas.1015247108. Epub 2011 Aug 1.
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Titer improvement of iso-migrastatin in selected heterologous Streptomyces hosts and related analysis of mRNA expression by quantitative RT-PCR.
Appl Microbiol Biotechnol. 2011 Mar;89(6):1709-19. doi: 10.1007/s00253-010-3025-1. Epub 2010 Dec 4.
6
Multifaceted modes of action for the glutarimide-containing polyketides revealed.
Chembiochem. 2010 Sep 24;11(14):1951-4. doi: 10.1002/cbic.201000370.
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Biosynthesis of polyketides by trans-AT polyketide synthases.
Nat Prod Rep. 2010 Jul;27(7):996-1047. doi: 10.1039/b816430b. Epub 2010 May 12.
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Migrastatin analogues target fascin to block tumour metastasis.
Nature. 2010 Apr 15;464(7291):1062-6. doi: 10.1038/nature08978.
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On the potential of natural products in the discovery of pharma leads: a case for reassessment.
Nat Prod Rep. 2010 Aug;27(8):1114-6. doi: 10.1039/c003211p. Epub 2010 Apr 9.

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