天然产物在药物先导物发现中的潜力：重新评估的案例。
On the potential of natural products in the discovery of pharma leads: a case for reassessment.
机构信息
Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
出版信息
Nat Prod Rep. 2010 Aug;27(8):1114-6. doi: 10.1039/c003211p. Epub 2010 Apr 9.
DOI:10.1039/c003211p
PMID:20383353
Abstract
The central proposition advanced herein is that complex target oriented synthesis, enabled by historic advances in methodology, has enormously expanded the scope of the possible. Accordingly, natural products, a proven long-term source of pharma discovery, re-emerge as potentially valuable elements for synthesis-driven pharma exploitation.
摘要
本文提出的中心论点是，得益于方法学的历史进步，复杂的目标导向合成极大地扩展了可能性的范围。因此，作为药物发现的长期来源，天然产物重新成为合成驱动药物开发的潜在有价值的元素。
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