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腺样体扁桃体切除术真的能减少小儿上呼吸道感染的门诊就诊次数吗?一项台湾的全国性数据库研究。

Does Adenotonsillectomy really reduced clinic visits for pediatric upper respiratory tract infections? A national database study in Taiwan.

作者信息

Tsou Yung-An, Lin Che-Chen, Lai Chih-Ho, Wang Ching-Yuan, Lin Chia-Der, Chen Pei-Chun, Tsai I-Ju, Chen Chuan-Mu, Sung Fung-Chang, Tsai Ming-Hsui

机构信息

Department of Otolaryngology-Head and Neck Surgery, China Medical University Hospital, Taichung, Taiwan.

出版信息

Int J Pediatr Otorhinolaryngol. 2013 May;77(5):677-81. doi: 10.1016/j.ijporl.2013.01.011. Epub 2013 Feb 8.

Abstract

OBJECTIVE

To investigate whether adenotonsillectomy reduces upper respiratory tract infections (URIs) in the pediatric population.

METHODS AND SUBJECTS

We identified 415 children, aged ≤18 years who had undergone adenoidectomy and/or tonsillectomy during the period from 1999 to 2006, from the Taiwan National Health Insurance Research Database. The comparison group consisted of 1630 children without the surgery randomly selected from the same database frequency matched with sex, age and the surgery date (index date). Changes in physician visits for URIs 2-year period before and 2-year period after the index date were compared between the two groups of children.

RESULTS

The number of outpatient visits for URIs decreased with time, children with tonsillectomy and/or adenoidectomy had a greater reduction than comparison children (mean changes, -14 times and -6 times, respectively) in the 2-year period after the index date. Multivariate analyses using generalized estimated equation revealed a significant effect in reducing URIs visits from the surgery (relative ratio=0.85, p<0.0001), strongest for children undergoing both tonsillectomy and adenoidectomy (relative ratio=0.76, p<0.0001). The association between surgery and the decrease in URIs was more pronounced for children aged 12 years and less.

CONCLUSION

This population-based study suggests that tonsillectomy and/or adenoidectomy is associated with fewer physician visits for URIs. The association is weakened in old children.

摘要

目的

探讨腺样体扁桃体切除术是否能减少儿科人群的上呼吸道感染(URIs)。

方法与研究对象

我们从台湾国民健康保险研究数据库中识别出415名年龄≤18岁、在1999年至2006年期间接受过腺样体切除术和/或扁桃体切除术的儿童。对照组由1630名未接受手术的儿童组成,这些儿童是从同一数据库中随机选取的,在性别、年龄和手术日期(索引日期)方面进行了频率匹配。比较两组儿童在索引日期前2年和索引日期后2年期间因URIs就诊的变化情况。

结果

因URIs的门诊就诊次数随时间减少,在索引日期后的2年期间,接受扁桃体切除术和/或腺样体切除术的儿童减少幅度大于对照组儿童(平均变化分别为-14次和-6次)。使用广义估计方程进行的多变量分析显示,手术对减少URIs就诊有显著效果(相对比率=0.85,p<0.0001),对于同时接受扁桃体切除术和腺样体切除术的儿童效果最强(相对比率=0.76,p<0.0001)。手术与URIs减少之间的关联在12岁及以下儿童中更为明显。

结论

这项基于人群的研究表明,扁桃体切除术和/或腺样体切除术与因URIs就诊次数减少有关。这种关联在大龄儿童中有所减弱。

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