Rossi M, Mennini G, Lai Q, Ginanni Corradini S, Drudi F M, Pugliese F, Berloco P B
Department of General Surgery and Transplantation "P. Stefanini", University "La Sapienza", Rome, Italy.
J Ultrasound. 2007 Mar;10(1):28-45. doi: 10.1016/j.jus.2007.02.006. Epub 2007 Apr 16.
Orthotopic liver transplantation (OLT) involves the substitution of a diseased native liver with a normal liver (or part of one) taken from a deceased or living donor. Considered an experimental procedure through the 1980s, OLT is now regarded as the treatment of choice for a number of otherwise irreversible forms of acute and chronic liver disease.The first human liver transplantation was performed in the United States in 1963 by Prof. T.E. Starzl of the University of Colorado. The first OLT to be performed in Italy was done in 1982 by Prof. R. Cortesini. The procedure was successfully performed at the Policlinico Umberto I of the University of Rome (La Sapienza).The paper reports the indications for liver transplantation, donor selection and organ allocation in our experience, surgical technique, immunosuppression, complications and results of liver transplantation in our center.
原位肝移植(OLT)是指用取自已故或活体供体的正常肝脏(或部分肝脏)替换患病的天然肝脏。在20世纪80年代,OLT被视为一种实验性手术,如今它被认为是多种原本不可逆转的急慢性肝病的首选治疗方法。1963年,美国科罗拉多大学的T.E. 斯塔兹教授进行了首例人体肝移植手术。1982年,意大利的R. 科尔泰西尼教授进行了首例原位肝移植手术。该手术在罗马大学(“La Sapienza”)的翁贝托一世综合医院成功实施。本文报告了我们中心肝移植的适应证、供体选择和器官分配经验、手术技术、免疫抑制、并发症及肝移植结果。