结肠前瘤病变中的基因组不稳定性。
Genomic instability in pre-neoplastic colonic lesions.
机构信息
Department of Cancer Studies and Molecular Medicine, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, UK.
出版信息
Oncogene. 2013 Nov 14;32(46):5331-2. doi: 10.1038/onc.2013.21. Epub 2013 Feb 11.
Abstract
Genomic instability is a characteristic of most cancers and it is argued that genomic instability is a driving force for tumorigenesis. Data herein demonstrate that genomic instability, as evidenced by microsatellite instability (MSI) and promoter methylation of DNA mismatch repair genes, is common in individual glands of pre-malignant colorectal lesions and raises interesting questions about the role of MSI in the development of colorectal carcinoma.
摘要
基因组不稳定性是大多数癌症的特征，有人认为基因组不稳定性是肿瘤发生的驱动力。本文中的数据表明，微卫星不稳定性（MSI）和 DNA 错配修复基因启动子甲基化等基因组不稳定性在癌前结直肠病变的单个腺体中很常见，这引发了关于 MSI 在结直肠癌发展中的作用的有趣问题。
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本文引用的文献
1
Modelling the evolution of genetic instability during tumour progression.肿瘤演进过程中遗传不稳定性的演变模型。
Evol Appl. 2013 Jan;6(1):20-33. doi: 10.1111/eva.12024. Epub 2012 Nov 26.
2
A study of genomic instability in early preneoplastic colonic lesions.研究早期前瘤性结肠病变中的基因组不稳定性。
Oncogene. 2013 Nov 14;32(46):5333-7. doi: 10.1038/onc.2012.584. Epub 2012 Dec 17.
3
Genetic instability is not a requirement for tumor development.基因不稳定并非肿瘤发生的必要条件。
Cancer Res. 2008 May 15;68(10):3558-60; discussion 3560-1. doi: 10.1158/0008-5472.CAN-07-6544.
4
The combination of genetic instability and clonal expansion predicts progression to esophageal adenocarcinoma.基因不稳定性与克隆性扩增相结合预示着向食管腺癌进展。
Cancer Res. 2004 Oct 15;64(20):7629-33. doi: 10.1158/0008-5472.CAN-04-1738.
5
6
Population-based molecular detection of hereditary nonpolyposis colorectal cancer.基于人群的遗传性非息肉病性结直肠癌分子检测
J Clin Oncol. 2000 Jun;18(11):2193-200. doi: 10.1200/JCO.2000.18.11.2193.
7
Genetic susceptibility to non-polyposis colorectal cancer.非息肉病性结直肠癌的遗传易感性。
J Med Genet. 1999 Nov;36(11):801-18.
8
Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers.表观遗传表型可区分微卫星稳定型和不稳定型结直肠癌。
Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12661-6. doi: 10.1073/pnas.96.22.12661.
9
Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability.微卫星不稳定的结肠癌中hMLH1启动子的高甲基化
Cancer Res. 1998 Aug 1;58(15):3455-60.
10
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma.结直肠癌中hMLH1启动子高甲基化的发生率及功能后果
Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6870-5. doi: 10.1073/pnas.95.12.6870.
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