[采用经典恒温加速试验法对白菊和贡菊进行稳定性预测]

[Stable life predection of Hangbaiju and Gongju by classic constant temperature accelerated test method].

作者信息

Zhang Da-Peng, Xue Zhi-Ping, Liu Jie, Kang Wen-Yi

机构信息

Institute of Chinese Materia Medica, Henan University, Kaifeng 475004, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2012 Nov;37(21):3182-4.

PMID:23397708

Abstract

OBJECTIVE

To study the stability of chlorogenic acid, cynaroside and 3,5-O-discaffeoylquinc acid in Hangbaiju and Gongju and to predict their term of validity.

METHOD

Hangbaiju and Gongju were incubated in an environmental chamber at different temperatures and relative humidities. After the incubation, quantitative determination of chlorogenic acid, cynaroside, 3,5-O-discaffeoylquinc acid in Hangbaiju and Gongju were measured by HPLC. The effective period of the preparation was calculated according to Arrhinius index law. Quantitative determination of 3,5-O-discaffeoylquinc acid, cynaroside, chlorogenic acid in Hangju and Gongju were analyzed by HPLC.

RESULT

The stable life of Hangbaiju has been determined as 2.25 years. The stable life of Gongju has been determined as 4.31 years.

CONCLUSION

The high temperature is not conducive to the stability of Hangbaiju and Gongju, which needs to be placed in a dark and cool place.

摘要

目的

研究杭白菊和贡菊中绿原酸、木犀草苷和3,5 - O - 二咖啡酰奎宁酸的稳定性，并预测其有效期。

方法

将杭白菊和贡菊在不同温度和相对湿度的环境箱中进行孵育。孵育后，采用高效液相色谱法测定杭白菊和贡菊中绿原酸、木犀草苷、3,5 - O - 二咖啡酰奎宁酸的含量。根据Arrhinius指数定律计算制剂的有效期。采用高效液相色谱法分析杭菊和贡菊中3,5 - O - 二咖啡酰奎宁酸、木犀草苷、绿原酸的含量。