铑催化的末端炔烃与缺电子烯烃的分子间[2 + 2]环加成反应。
Rhodium-catalyzed intermolecular [2 + 2] cycloaddition of terminal alkynes with electron-deficient alkenes.
机构信息
Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan.
出版信息
Org Lett. 2013 Mar 1;15(5):1024-7. doi: 10.1021/ol303510k. Epub 2013 Feb 11.
PMID:23398205
Abstract
The first catalytic intermolecular [2 + 2] cycloaddition of terminal alkynes with electron-deficient alkenes is reported. The reaction proceeds with an 8-quinolinolato rhodium/phosphine catalyst system to give cyclobutenes from various substrates having polar functional groups in high yields with complete regioselectivity.
摘要
首次报道了末端炔烃与缺电子烯烃的催化分子间[2+2]环加成反应。该反应在 8-喹啉醇铑/膦催化剂体系的作用下进行，各种带有极性官能团的底物以高产率和完全的区域选择性得到环丁烯产物。
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