Departamento de Oncologia Clínica e Experimental, Disciplina de Hematologia e Hemoterapia, Universidade Federal de São Paulo , UNIFESP, São Paulo , Brazil.
Leuk Lymphoma. 2013 Oct;54(10):2177-80. doi: 10.3109/10428194.2013.764423. Epub 2013 Mar 4.
The aim of the present study was to determine whether there is an association between serum free light chains (sFLC) quantification and the development of post-transplant lymphoproliferative disorder (PTLD), using serum samples from a nested case-control cohort of patients with renal transplant. Ten new cases of PTLD and 46 controls were enrolled. Additional comparison groups consisted of five human immunodeficiency virus (HIV)-infected individuals, five with untreated Hodgkin lymphoma and six normal individuals. Serum κ and λ FLC concentrations were measured by nephelometry and compared with reference ranges (normal and renal ranges). κ and/or λ were above the normal range in 90% of cases and in 65% of matched controls. There was no statistically significant difference between all groups, except for λ FLC concentrations between cases of PTLD and normal individuals (p = 0.016). The κ/λ sFLC ratios of cases and controls were within the renal range and normal range. Our results suggest that sFLC are not useful to predict PTLD development in renal transplant recipients.
本研究旨在通过对肾移植患者的嵌套病例对照队列的血清样本进行检测，确定血清游离轻链（sFLC）定量与移植后淋巴增殖性疾病（PTLD）的发展之间是否存在关联。纳入了 10 例新的 PTLD 病例和 46 例对照。另外还比较了 5 例人类免疫缺陷病毒（HIV）感染个体、5 例未经治疗的霍奇金淋巴瘤患者和 6 例正常个体。采用散射比浊法检测血清 κ 和 λ FLC 浓度，并与参考范围（正常范围和肾范围）进行比较。90%的病例和 65%的匹配对照的 κ 和/或 λ 值均高于正常范围。除了 PTLD 病例和正常个体之间的 λ FLC 浓度存在统计学差异（p = 0.016）外，所有组之间均无统计学差异。病例和对照的 κ/λ sFLC 比值均在肾范围和正常范围内。我们的结果表明，sFLC 对于预测肾移植受者的 PTLD 发展并不有用。
