Frankland Paul W
Frankland, Program in Neurosciences and Mental Health, The Hospital for Sick Children, Departments of Psychology and Physiology, University of Toronto, Toronto, Ontario, Canada M5G 1X8.
Behav Neurosci. 2013 Feb;127(1):126-9. doi: 10.1037/a0031512.
The continued production of new dentate granule cells throughout life has led to the idea that neurogenesis critically modulates hippocampal memory function. Consistent with this view, many studies have shown that experimental reduction of adult neurogenesis impairs hippocampal memory formation. However, impairments are not universally observed following suppression of adult neurogenesis. A new article by Urbach et al. falls into this latter category. A global deletion of the cyclin D2--a cell cycle regulation gene--induces a profound reduction in adult neurogenesis. Yet, despite this reduction, this knockout mouse was able to acquire a hippocampus-dependent spatial memory normally. These results suggest that ongoing adult neurogenesis is not necessary for many forms of hippocampus-dependent learning, and in this commentary, I discuss the implications of these types of results for the field.
一生中持续产生新的齿状颗粒细胞引发了这样一种观点，即神经发生对海马体记忆功能具有关键的调节作用。与这一观点一致的是，许多研究表明，实验性减少成体神经发生会损害海马体记忆形成。然而，在抑制成体神经发生后，并非普遍观察到损伤。乌尔巴赫等人的一篇新文章就属于后一种情况。细胞周期蛋白D2（一种细胞周期调节基因）的整体缺失会导致成体神经发生显著减少。然而，尽管有这种减少，这种基因敲除小鼠仍能够正常获得依赖海马体的空间记忆。这些结果表明，持续的成体神经发生对于许多形式的依赖海马体的学习并非必要，在这篇评论中，我将讨论这类结果对该领域的影响。
