Dicker R M, James N, Cunha B A
Winthrop-University Hospital, Mineola, New York.
Ann Intern Med. 1990 Jun 15;112(12):957-8. doi: 10.7326/0003-4819-112-12-957.
Causes of the eosinophilia-myalgia syndrome other than L-tryptophan include parasitic myositis (that is, trichinosis), acute tropical myositis, sarcoidosis, granulomatous myositis, polymyositis, collagen vascular diseases, neoplastic myositis, and eosinophilic myositis. Some of these can be excluded by the absence of associated findings, that is, sarcoidosis, collagen vascular disease, neoplastic myositis; or on epidemiologic grounds, for example, acute tropical myositis. A muscle biopsy is diagnostic for trichinosis and for granulomatous, neoplastic, and eosinophilic myositis. A normal erythrocyte sedimentation rate militates against but does not rule out neoplastic or collagen vascular disease-associated myositis. The erythrocyte sedimentation rate may be elevated in most of these disorders although trichinosis is characterized by a very low rate. Most conditions associated with eosinophilia are characterized by both blood and local tissue eosinophilia.
除L-色氨酸外，嗜酸性粒细胞增多性肌痛综合征的病因还包括寄生虫性肌炎（即旋毛虫病）、急性热带性肌炎、结节病、肉芽肿性肌炎、多发性肌炎、胶原血管病、肿瘤性肌炎和嗜酸性粒细胞性肌炎。其中一些病因可通过缺乏相关表现来排除，如结节病、胶原血管病、肿瘤性肌炎；或基于流行病学依据排除，如急性热带性肌炎。肌肉活检对旋毛虫病以及肉芽肿性、肿瘤性和嗜酸性粒细胞性肌炎具有诊断价值。红细胞沉降率正常虽不利于肿瘤性或胶原血管病相关性肌炎的诊断，但不能排除。在大多数这些疾病中红细胞沉降率可能升高，尽管旋毛虫病的特点是红细胞沉降率极低。大多数与嗜酸性粒细胞增多相关的病症都具有血液和局部组织嗜酸性粒细胞增多的特征。
