Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, Vancouver, BC, Canada.
Adv Anat Pathol. 2013 Mar;20(2):110-6. doi: 10.1097/PAP.0b013e3182862724.
Since the mapping of the human genome and the advent of next-generation sequencing technology thorough examination of the cancer genome has become a reality. Over the last few years several studies have used next-generation sequencing technology to investigate the genetic landscape of Hodgkin and non-Hodgkin lymphomas, identifying novel genetic mutations and gene rearrangements that have shed new light on the underlying tumor biology in these diseases as well as identifying possible targets for directed therapy. This review covers the major discoveries in lymphoma using next-generation sequencing technology.
自从人类基因组图谱的绘制和下一代测序技术的出现，对癌症基因组进行全面检查已经成为现实。在过去的几年中，有几项研究利用下一代测序技术来研究霍奇金和非霍奇金淋巴瘤的遗传图谱，确定了新的遗传突变和基因重排，这些发现为这些疾病的肿瘤生物学提供了新的认识，并确定了可能的靶向治疗靶点。本文综述了利用下一代测序技术在淋巴瘤方面的主要发现。
