Faculdade de Medicina, Programa de Pós-Graduação em Medicina: Ciências Médicas, Porto Alegre, Brazil.
Arch Gynecol Obstet. 2013 Jul;288(1):183-9. doi: 10.1007/s00404-013-2745-8. Epub 2013 Feb 12.
This study aims to evaluate and to compare the performance of cervical digital photography (CDP) to the visual inspection with acetic acid (VIA) and visual inspection with Lugol's iodine (VILI) methods for screening the uterine cervix cancer and its precursor lesions in developing countries.
A cross-sectional study was performed in Brazil. 176 women were evaluated by VIA, VILI, CDP with acetic acid and CDP with Lugol's iodine. Kappa statistic was used to estimate the interobserver and intermethod agreement. Sensitivity, specificity and diagnostic accuracy of the four methods (VIA, VILI, CDP with acetic acid, CDP with Lugol's iodine) was calculated.
Interobserver agreement for CDP with acetic acid was K = 0.441 and for CDP with Lugol's iodine was K = 0.533; intermethod agreement of VIA and CDP with acetic acid, K = 0.559; and of VILI and CDP with Lugol's iodine, K = 0.507. Sensitivity and specificity of CDP with acetic acid were 84.00 and 95.83 %, and of CDP with Lugol's iodine were 88.00 and 97.26 %, respectively. The diagnostic accuracy of CDP with acetic acid and CDP with Lugol's iodine was 92.78 and 94.90 %, respectively.
This was the first study to assess the CDP with Lugol's iodine performance, which had similar performance to the CDP with acetic acid. CDP is considered a promising method for screening the uterine cervix cancer and its precursor lesions in developing countries.
本研究旨在评估和比较宫颈数字摄影（CDP）与醋酸视觉检查（VIA）和卢戈氏碘液视觉检查（VILI）在发展中国家筛查宫颈癌及其前体病变的性能。
在巴西进行了一项横断面研究。176 名女性接受了 VIA、VILI、醋酸 CDP 和卢戈氏碘液 CDP 检查。采用 Kappa 统计评估观察者间和方法间的一致性。计算了四种方法（VIA、VILI、醋酸 CDP 和卢戈氏碘液 CDP）的敏感性、特异性和诊断准确性。
醋酸 CDP 的观察者间一致性为 K = 0.441，卢戈氏碘液 CDP 的观察者间一致性为 K = 0.533；VIA 和醋酸 CDP 的方法间一致性为 K = 0.559；VILI 和卢戈氏碘液 CDP 的方法间一致性为 K = 0.507。醋酸 CDP 的敏感性和特异性分别为 84.00%和 95.83%，卢戈氏碘液 CDP 的敏感性和特异性分别为 88.00%和 97.26%。醋酸 CDP 和卢戈氏碘液 CDP 的诊断准确性分别为 92.78%和 94.90%。
这是首次评估卢戈氏碘液 CDP 性能的研究，其性能与醋酸 CDP 相似。CDP 被认为是发展中国家筛查宫颈癌及其前体病变的一种很有前途的方法。
