超重是否会增加儿童早期动脉硬化的风险？

Is Overweight a Risk of Early Atherosclerosis in Childhood?

机构信息

Department of Cardiology, Faculty of Medicine, Namık Kemal University Medical School, Turkey.

Department of Pediatrics, Faculty of Medicine, Namık Kemal University Medical School, Turkey.

出版信息

Angiology. 2020 May;71(5):438-443. doi: 10.1177/0003319713476134. Epub 2013 Feb 11.

DOI:10.1177/0003319713476134

PMID:23401628

Abstract

We measured brachial artery flow-mediated dilatation (FMD) and common carotid intima-media thickness (cIMT) in overweight (n = 67) and normal weight children (n = 115, controls). Age at examination ranged from 72 to 182 months (mean 123 ± 27). Compared to controls, the overweight children had increased weight, waist and hip circumference, systolic and diastolic blood pressures (all < .001), right and left mean cIMT (mm; 0.58 [0.42-0.68] vs 0.44 [0.3-0.64], < .001 and 0.56 [0.32-0.70] vs 0.44 [0.3-0.60], < .001), respectively, and decreased FMD (%; 6.25 [3.33-19.05] vs 7.69 [3.45-16], < .001). The cIMT and FMD were closely related to the serum insulin concentrations. Age, waist circumferences, and serum triglycerides were independent predictive risk factors for increased cIMT, and fasting glucose and BMI were independent predictive variables for decreased FMD. Overweight children are also potentially at risk of early atherosclerosis as much as obese children.

摘要

我们测量了超重（n = 67）和正常体重儿童（n = 115，对照组）的肱动脉血流介导的扩张（FMD）和颈总动脉内膜中层厚度（cIMT）。检查时的年龄范围为 72 至 182 个月（平均 123 ± 27）。与对照组相比，超重儿童的体重、腰围和臀围、收缩压和舒张压（均<.001）、右和左平均 cIMT（mm；0.58 [0.42-0.68] vs 0.44 [0.3-0.64]，<.001 和 0.56 [0.32-0.70] vs 0.44 [0.3-0.60]，<.001）以及 FMD（%；6.25 [3.33-19.05] vs 7.69 [3.45-16]，<.001）均增加。cIMT 和 FMD 与血清胰岛素浓度密切相关。年龄、腰围和血清甘油三酯是 cIMT 增加的独立预测危险因素，而空腹血糖和 BMI 是 FMD 降低的独立预测变量。超重儿童也像肥胖儿童一样，存在早期动脉粥样硬化的潜在风险。