Oldenborg Per-Arne
Section for Histology and Cell Biology, Department of Integrative Medical Biology, Umeå University, 901 87 Umeå, Sweden.
ISRN Hematol. 2013;2013:614619. doi: 10.1155/2013/614619. Epub 2013 Jan 21.
Interactions between cells and their surroundings are important for proper function and homeostasis in a multicellular organism. These interactions can either be established between the cells and molecules in their extracellular milieu, but also involve interactions between cells. In all these situations, proteins in the plasma membranes are critically involved to relay information obtained from the exterior of the cell. The cell surface glycoprotein CD47 (integrin-associated protein (IAP)) was first identified as an important regulator of integrin function, but later also was shown to function in ways that do not necessarily involve integrins. Ligation of CD47 can induce intracellular signaling resulting in cell activation or cell death depending on the exact context. By binding to another cell surface glycoprotein, signal regulatory protein alpha (SIRPα), CD47 can regulate the function of cells in the monocyte/macrophage lineage. In this spotlight paper, several functions of CD47 will be reviewed, although some functions may be more briefly mentioned. Focus will be on the ways CD47 regulates hematopoietic cells and functions such as CD47 signaling, induction of apoptosis, and regulation of phagocytosis or cell-cell fusion.
细胞与其周围环境之间的相互作用对于多细胞生物体的正常功能和内环境稳定至关重要。这些相互作用既可以在细胞与细胞外环境中的分子之间建立，也涉及细胞之间的相互作用。在所有这些情况下，质膜中的蛋白质对于传递从细胞外部获得的信息至关重要。细胞表面糖蛋白CD47（整合素相关蛋白（IAP））最初被鉴定为整合素功能的重要调节因子，但后来也被证明以不一定涉及整合素的方式发挥作用。CD47的连接可诱导细胞内信号传导，根据具体情况导致细胞活化或细胞死亡。通过与另一种细胞表面糖蛋白信号调节蛋白α（SIRPα）结合，CD47可以调节单核细胞/巨噬细胞谱系中细胞的功能。在这篇聚焦文章中，将回顾CD47的几种功能，尽管有些功能可能会更简要地提及。重点将放在CD47调节造血细胞的方式以及诸如CD47信号传导、凋亡诱导、吞噬作用或细胞间融合的调节等功能上。
