Scalvenzi Massimiliano, Palmisano Franco, Cacciapuoti Sara, Migliaro Fiorella, Siano Maria, Staibano Stefania, Tornillo Luigi, Costa Claudia
Department of Dermatology, Federico II University, via Pansini 5, 80131 Naples, Italy.
Case Rep Dermatol Med. 2013;2013:473635. doi: 10.1155/2013/473635. Epub 2013 Jan 16.
Congenital malignant melanoma (CMM) is a rare condition that is defined as malignant melanoma recognized at birth. CMM may develop in utero in one of three ways: (1) transmission by metastasis through the placenta from a mother with melanoma; (2) primary melanoma arising within a giant congenital melanocytic naevus (GCMN); (3) primary de novo cutaneous CMM arising in utero. CMM can be confused clinically and histologically with benign proliferative melanocytic lesions such as giant congenital nevi. We describe the case of a patient presenting a GCMN with proliferative nodules, clinically and dermoscopically resembling a CMM, demonstrating the importance of caution in making a diagnosis of MM and highlighting the possibility that benign lesions as GCMN can mimic a malignant melanoma in this age group.
先天性恶性黑色素瘤（CMM）是一种罕见病症，定义为出生时即被识别出的恶性黑色素瘤。CMM可在子宫内以三种方式之一发展：（1）通过胎盘从患有黑色素瘤的母亲转移传播；（2）在巨大先天性黑素细胞痣（GCMN）内发生原发性黑色素瘤；（3）子宫内原发性新发皮肤CMM。CMM在临床和组织学上可能与良性增生性黑素细胞病变（如巨大先天性痣）相混淆。我们描述了一例患者，其患有带有增生性结节的GCMN，临床和皮肤镜检查表现类似于CMM，这表明在诊断黑色素瘤时谨慎的重要性，并强调了在该年龄组中GCMN等良性病变可能模仿恶性黑色素瘤的可能性。
