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儿童巨大先天性黑素细胞痣伴卫星斑痣中的恶性黑素瘤:一种罕见实体。

Malignant melanoma in a child with giant congenital melanocytic nevus and satellite flekers: A rare entity.

机构信息

Department of Pathology, V.M.M.C and Safdarjung Hospital, New Delhi, India.

出版信息

Diagn Cytopathol. 2020 Jun;48(6):564-566. doi: 10.1002/dc.24408. Epub 2020 Mar 17.

Abstract

Malignant melanomas in the pediatric age are remarkably rare representing 0.9% of various pediatric malignancies. Congenital nevi occur in 1 in 100 newborns, whereas giant congenital melanocytic nevus (GCMN) measuring more than 20 cm is seen in 1 in 20 000 cases. Very few cases of malignant melanoma arising from GCMN have been described in English literature. The risk of developing malignant melanoma from GCMN is believed to be directly proportional to the size of the nevus and varies from 2.6% to 20% depending on the size of nevus. We present a case of malignant melanoma in a 12-year-old female child who had a congenital giant nevus and multiple satellite flekers all over the body.

摘要

儿童期恶性黑色素瘤非常罕见,占各种儿科恶性肿瘤的 0.9%。先天性痣在每 100 名新生儿中出现 1 例,而大于 20cm 的巨大先天性黑色素细胞痣(GCMN)在每 20000 例中出现 1 例。英文文献中很少有描述源自 GCMN 的恶性黑色素瘤的病例。人们认为,GCMN 发生恶性黑色素瘤的风险与痣的大小成正比,根据痣的大小,风险从 2.6%到 20%不等。我们报告了一例 12 岁女性儿童的恶性黑色素瘤病例,该患儿患有先天性巨大痣和全身多发性卫星斑。

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