牙周炎的补体靶向治疗。
Complement-targeted therapeutics in periodontitis.
机构信息
Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Adv Exp Med Biol. 2013;735:197-206. doi: 10.1007/978-1-4614-4118-2_13.
Abstract
Periodontitis is a prevalent oral chronic inflammatory disease which, in severe forms, may exert a major impact on systemic health. Clinical and histological observations, as well as experimental animal studies, suggest involvement of the complement system in periodontitis. However, the precise roles of the various complement components and pathways in periodontitis have only recently started to be elucidated. In this chapter, we review recent progress in the field and discuss the potential of complement-targeted therapeutics in the treatment of periodontitis.
摘要
牙周炎是一种普遍的口腔慢性炎症性疾病，在严重的情况下，可能对全身健康产生重大影响。临床和组织学观察以及实验动物研究表明，补体系统参与了牙周炎的发生。然而，各种补体成分和途径在牙周炎中的确切作用直到最近才开始被阐明。在本章中，我们回顾了该领域的最新进展，并讨论了补体靶向治疗在牙周炎治疗中的潜力。
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本文引用的文献
1
Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement.
Cell Host Microbe. 2011 Nov 17;10(5):497-506. doi: 10.1016/j.chom.2011.10.006. Epub 2011 Oct 27.
2
How has neutrophil research improved our understanding of periodontal pathogenesis?
J Clin Periodontol. 2011 Mar;38 Suppl 11:49-59. doi: 10.1111/j.1600-051X.2010.01678.x.
3
The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss.
J Immunol. 2011 Jan 15;186(2):869-77. doi: 10.4049/jimmunol.1003252. Epub 2010 Dec 13.
4
A critical role for C5L2 in the pathogenesis of experimental allergic asthma.
J Immunol. 2010 Dec 1;185(11):6741-52. doi: 10.4049/jimmunol.1000892. Epub 2010 Oct 25.
5
Prevention: Reducing the risk of CVD in patients with periodontitis.
Nat Rev Cardiol. 2010 Sep;7(9):479-80. doi: 10.1038/nrcardio.2010.120.
6
Complement: a key system for immune surveillance and homeostasis.
Nat Immunol. 2010 Sep;11(9):785-97. doi: 10.1038/ni.1923. Epub 2010 Aug 19.
7
"Gum bug, leave my heart alone!"--epidemiologic and mechanistic evidence linking periodontal infections and atherosclerosis.
J Dent Res. 2010 Sep;89(9):879-902. doi: 10.1177/0022034510375281. Epub 2010 Jul 16.
8
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9
Microbial hijacking of complement-toll-like receptor crosstalk.
Sci Signal. 2010 Feb 16;3(109):ra11. doi: 10.1126/scisignal.2000697.
10
Crosstalk pathways between Toll-like receptors and the complement system.
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