University of Louisville School of Dentistry, Division of Oral Health and Systemic Disease, Louisville, KY, USA.
Trends Immunol. 2010 Apr;31(4):154-63. doi: 10.1016/j.it.2010.01.002. Epub 2010 Feb 10.
The Toll-like receptors (TLRs) and complement are key innate defense systems that are triggered rapidly upon infection. Although both systems have been investigated primarily as separate entities, an emerging body of evidence indicates extensive crosstalk between complement and TLR signaling pathways. Analysis of these data suggests that the complement-TLR interplay reinforces innate immunity or regulates excessive inflammation, through synergistic or antagonistic interactions, respectively. However, the facility of complement and TLRs for communication is exploited by certain pathogens as a means to modify the host response in ways that favor the persistence of the pathogens. Further elucidation of regulatory links between complement and TLRs is essential for understanding their complex roles in health and disease.
Toll 样受体 (TLRs) 和补体是感染时迅速被触发的主要固有防御系统。尽管这两个系统主要作为独立实体进行研究，但越来越多的证据表明补体和 TLR 信号通路之间存在广泛的串扰。对这些数据的分析表明，补体-TLR 相互作用通过协同或拮抗相互作用，分别增强固有免疫或调节过度炎症。然而，某些病原体利用补体和 TLR 进行通讯的便利性，以改变宿主反应的方式，有利于病原体的持续存在。进一步阐明补体和 TLR 之间的调节联系对于理解它们在健康和疾病中的复杂作用至关重要。
