Aagaard Lise
Forskningsenheden for Klinisk Farmakologi, Institut for Sundhedstjenesteforskning, Det Sundhedsvidenskabelige Fakultet, Syddansk Universitet, J.B. Winsløws Vej 19, 5000 Odense C, Denmark.
Ugeskr Laeger. 2013 Feb 4;175(6):342-5.
Knowledge of adverse drug reactions (ADRs) from medicine use in children is limited. We analyzed 4,500 ADRs submitted for children from ages 0 to 17 years to the Danish National ADR Database in the period from 1998 to 2007 with respect to occurrence, seriousness and type of reported ADRs, therapeutic group, age, gender and reporter. 40 per cent of the reported ADRs were serious, and fatal cases were found. Half of the ADRs were reported in children from 0 up to 2 years of age. The majority of the ADRs were reported for immunization therapies, antibiotics and psychotropic medicine. Physicians reported 90% of all ADRs.
关于儿童用药不良反应（ADR）的知识有限。我们分析了1998年至2007年期间提交至丹麦国家ADR数据库的4500例0至17岁儿童的ADR，内容涉及报告的ADR的发生情况、严重程度和类型、治疗组、年龄、性别及报告者。报告的ADR中有40%为严重不良反应，且发现了致命病例。一半的ADR报告来自0至2岁的儿童。大多数ADR报告涉及免疫疗法、抗生素和精神药物。所有ADR中有90%是由医生报告的。
