Kiellberg Larsen Helle
Dermato-venerologisk Afdeling D, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 København NV, Denmark.
Ugeskr Laeger. 2013 Feb 4;175(6):345-9.
Anal intra-epithelial neoplasia is of high incidence in the post-highly active antiretroviral treatment era especially among men, who have sex with men (MSM). This article focuses on the relation between infection with oncogenic HPV types and anal intra-epithelial neoplasia, and the potential progression to anal cancer. Vaccine studies with the quadrivalent HPV vaccine in HIV-negative MSM shows promising results regarding preventing development of HGAIN.
肛门上皮内瘤变在高效抗逆转录病毒治疗时代后期发病率较高,尤其是在男男性行为者(MSM)中。本文重点关注致癌性人乳头瘤病毒(HPV)感染与肛门上皮内瘤变之间的关系,以及发展为肛门癌的潜在进程。针对HIV阴性男男性行为者的四价HPV疫苗的疫苗研究在预防高级别肛门上皮内瘤变(HGAIN)发展方面显示出了有前景的结果。